Ataxia telangiectasia and Rad3-related protein
Synonyms: FRP1, MEC1, “MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae)”, SCKL, SCKL1
ATR is serine/threonine kinase, which is activated in response to DNA damage in eukaryotic cells1. ATR and ATM are the most upstream kinases involved in the DNA damage response. However, their DNA-damage specificities are distinct and their functions are not redundant. Both kinases are a members of phosphatidylinositol-3-kinase-like kinase family (PIKKs).
ATR assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Maréchal, A., & Zou, L. (2013). DNA damage sensing by the ATM and ATR kinases. Cold Spring Harbor perspectives in biology, 5(9), a012716.