AURORA-A assay
Aurora kinase A
Synonyms: AIK, ARK1, AurA, BTAK, PPP1R47, “protein phosphatase 1, regulatory subunit 47”, STK7, STK15, STK6
Family: Other
Aurora kinases belong to the serine/threonine subclass of kinases and are involved in the regulation of mitosis1. They show increased expression level in a variety of solid and liquid tumors including lung, liver, breast and pancreatic tumors. Aurora A was shown to be essential for the centrosome and spindle functions2.
Aurora kinase A assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Yue Kong, Andreas Bender, and Aixia Yan. Identification of Novel Aurora Kinase A (AURKA) Inhibitors via Hierarchical Ligand-Based Virtual Screening. Journal of Chemical Information and Modeling. DOI: 10.1021/acs.jcim.7b00300
2. Stenoien DL, Sen S, Mancini MA, Brinkley BR. Dynamic association of a tumor amplified kinase, Aurora‐A, with the centrosome and mitotic spindle. Cytoskeleton. 2003 Jun 1;55(2):134-46.