AURORA-B assay
Aurora kinase B
Synonyms: Aik2, AIM-1, ARK2, AurB, “aurora-1”, “aurora-B”, IPL1, PPP1R48, “protein phosphatase 1, regulatory subunit 48”, STK5, STK12
Family: Other
Aurora kinases belong to the serine/threonine subclass of kinases and are involved in the regulation of mitosis1. They show increased expression level in a variety of solid and liquid tumours including lung, liver, breast and pancreatic tumors. Aurora B is a subunit of a chromosome passenger complex that is recruited to centromeres during mitosis2.
Aurora kinase B assay is run on mobility shift microfluidics platform, which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Yue Kong, Andreas Bender, and Aixia Yan. Identification of Novel Aurora Kinase A (AURKA) Inhibitors via Hierarchical Ligand-Based Virtual Screening. Journal of Chemical Information and Modeling. DOI: 10.1021/acs.jcim.7b00300
2. Santaguida S, Vernieri C, Villa F, Ciliberto A, Musacchio A. Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction. The EMBO journal. 2011 Apr 20;30(8):1508-19.