BMX non-receptor tyrosine kinase
Synonyms: “BTK-like on X chromosome”, ETK, PSCTK3
Family: TK (Tyrosine kinase)
Bmx kinase is a cytoplasmic tyrosine-protein kinase, which plays central but diverse modulatory roles in various signaling processes. It was suggested that Bmx may play an important role in the pathogenesis of numerous tumor types, including glioblastoma, prostate, breast and lung cancer1. Bmx can be inhibited by Btk inhibitor – ibrutinib2.
BMX kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Jarboe JS, Dutta S, Velu SE, Willey CD. Mini-review: bmx kinase inhibitors for cancer therapy. Recent patents on anti-cancer drug discovery. 2013 Sep 1;8(3):228-38.
2. He L, Li D, Zhang C, Bai P, Chen L. Discovery of (R)-5-(benzo [d][1, 3] dioxol-5-yl)-7-((1-(vinylsulfonyl) pyrrolidin-2-yl) methyl)-7H-pyrrolo [2, 3-d] pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC. Bioorganic & Medicinal Chemistry Letters. 2017 Sep 1;27(17):4171-5.