Breast tumour kinase
Family: TK (Tyrosine kinase)
BRK is intracellular protein kinase that is significantly overexpressed in a majority of breast tumors1. Brk is not expressed in the normal mammary gland, while in great tumour cells it promotes growth factor signaling and cell migration. Brk expression is also increased in a number of other epithelial tumors, including ovarian and colon cancer2.
BRK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Harvey AJ, Crompton MR. The Brk protein tyrosine kinase as a therapeutic target in cancer: opportunities and challenges. Anti-cancer drugs. 2004 Feb 1;15(2):107-11.
2. Brauer PM, Tyner AL. Building a better understanding of the intracellular tyrosine kinase PTK6—BRK by BRK. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2010 Aug 31;1806(1):66-73.