BRSK2 assay
Brain specific kinase 2
Synonyms: SAD-A, PEN11B, “serine/threonine kinase 29”, C11orf7, STK29
Family: CAMK (Ca2+/calmodulin- dependent protein kinase)
Brain-specific kinases (BRSK1/2) are AMP-activated protein kinase that are highly expressed in mammalian forebrain1. They play a role in in polarization of neurons and centrosome duplication1,2.
BRSK2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Bright NJ, Carling D, Thornton C. Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation. Journal of Biological Chemistry. 2008 May 30;283(22):14946-54.
2. Kishi M, Pan YA, Crump JG, Sanes JR. Mammalian SAD kinases are required for neuronal polarization. Science. 2005 Feb 11;307(5711):929-32.