BTK assay
Bruton tyrosine kinase
Synonyms: ATK, PSCTK1, XLA, AGMX1, IMD1
Family: TK (tyrosine kinase)
BTK is non-receptor tyrosine kinase, which plays a crucial role in B-cell development. BTK is known to be expressed in many haematopoietic cell types and participate in B cells in multiple pathways1. Btk expression is assumed to be a prerequisite for B-cell proliferation and survival2. BTK inhibitor, ibrutinib, is used to treat B-cells cancers.
BTK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Seda V, Mraz M. B‐cell receptor signalling and its crosstalk with other pathways in normal and malignant cells. European journal of haematology. 2015 Mar 1;94(3):193-205.
2. Mohamed AJ, Yu L, Bäckesjö CM, Vargas L, Faryal R, Aints A, Christensson B, Berglöf A, Vihinen M, Nore BF, Edvard Smith CI. Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunological reviews. 2009 Mar 1;228(1):58-73.