Bruton tyrosine kinase
Synonyms: ATK, PSCTK1, XLA, AGMX1, IMD1
Family: TK (tyrosine kinase)
BTK is non-receptor tyrosine kinase, which plays a crucial role in B-cell development. BTK is known to be expressed in many haematopoietic cell types and participate in B cells in multiple pathways1. Btk expression is assumed to be a prerequisite for B-cell proliferation and survival2. BTK inhibitor, ibrutinib, is used to treat B-cells cancers.
BTK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Seda V, Mraz M. B‐cell receptor signalling and its crosstalk with other pathways in normal and malignant cells. European journal of haematology. 2015 Mar 1;94(3):193-205.
2. Mohamed AJ, Yu L, Bäckesjö CM, Vargas L, Faryal R, Aints A, Christensson B, Berglöf A, Vihinen M, Nore BF, Edvard Smith CI. Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunological reviews. 2009 Mar 1;228(1):58-73.