Cyclin dependent kinase 5 (complex with p25)
Synonyms: cell division protein kinase 5
CDK5 is a proline-directed serine/threonine protein kinase and a member of cyclin dependent kinase family. CDK5 is a a crucial regulator of neuronal migration in the developing central nervous system1. CDK5 shows no enzymatic activity as a monomer, and has two binding partners p35 and p39. p25 is a truncated form of p35 and CDK5-p25 complex shows higher kinase activity and neurotoxicity2.
CDK5-p25 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Dhavan R, Tsai LH. A decade of CDK5. Nature reviews Molecular cell biology. 2001 Oct 1;2(10):749-59.
2. Camins A, Verdaguer E, Folch J, Canudas AM, Pallàs M. The role of CDK5/P25 formation/inhibition in neurodegeneration. Drug News Perspect. 2006 Oct 1;19(8):453-60.