CDK7-CYCLIN H assay
Cyclin dependent kinase 7 (complex with cyclin H)
Synonyms: CAK, CAK1, CDKN7, MO15, STK1
CDK7 is a serine/threonine protein kinase and a member of cyclin dependent kinase family. CDK7 forms the CDK-activating kinase (CAK) with cyclin H and MAT11. CAK activates downstream cell cycle CDKs, making CDK7 important regulator in cell cycle progression. CDK7 also phosphorylates serines in the carboxy-terminal domain of POLR2A, an essential step for efficient transcription2.
CDK7-CYCLIN H kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Kelso TW, Baumgart K, Eickhoff J, Albert T, Antrecht C, Lemcke S, Klebl B, Meisterernst M. CDK7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression and survival of tumor cells. Molecular and cellular biology. 2014 Jul 21:MCB-00595.
2. Greenall SA, Lim YC, Mitchell CB, Ensbey KS, Stringer BW, Wilding AL, O’Neill GM, McDonald KL, Gough DJ, Day BW, Johns TG. Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma. Oncogenesis. 2017 May 1;6(5):e336.