Checkpoint kinase 1
CHEK1 is a serine/threonine kinase, which is required for cell-cycle delays after DNA damage or blocked DNA replication1. CHEK1 kinase gets activated in response to diverse genotoxic insults2. The Chk1 kinase protein is largely restricted to S and G2 phases. Recent data suggest that activating, but not inhibiting, Chk1 in the absence of chemotherapy might represent an innovative approach to suppress tumor growth3.
CHEK1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Sørensen CS, Hansen LT, Dziegielewski J, Syljuåsen RG, Lundin C, Bartek J, Helleday T. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nature cell biology. 2005 Feb 1;7(2):195-201.
2. Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer cell. 2003 May 31;3(5):421-9.
3. Zhang Y, Hunter T. Roles of Chk1 in cell biology and cancer therapy. International journal of cancer. 2014 Mar 1;134(5):1013-23.