Casein kinase 1 delta
Synonyms: CKID, CKIdelta, HCKID
Family: CK1 (Casein Kinase 1)
CK1 kinases isoforms are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation1. Mammalian CK1δ was shown to be upregulated upon DNA damage and to phosphorylate the tumor suppressor protein p53, which is the guardian of the genome2. The CK1-DELTA and CK1-EPSILON isoforms have striking sequence similarity both the kinase domain and the non-catalytic C-terminal regions. CK1δ and CK1ε are known to be important regulators in the circadian rhythm of eukaryotic cells. Both these kinases are enriched and anchored in the centrosome, which enables them to influence the activity of regulatory centrosomal proteins3. Increased presence of CK1δ has also been detected in neoplasia, cells of hyperplastic B follicles and advanced B-cell lymphomas in p53-deficient mice2.
CK1-DELTA kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Schittek B, Sinnberg T. Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis. Molecular cancer. 2014 Oct 11;13(1):231.
2. Knippschild U, Wolff S, Giamas G, Brockschmidt C, Wittau M, Würl PU, Eismann T, Stöter M. The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Oncology Research and Treatment. 2005;28(10):508-14.
3. Sillibourne JE, Milne DM, Takahashi M, Ono Y, Meek DW. Centrosomal anchoring of the protein kinase CK1δ mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450. Journal of molecular biology. 2002 Sep 27;322(4):785-97.