CK1-DELTA

CK1 kinases isoforms are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation¹. Mammalian CK1δ was shown to be upregulated upon DNA damage and to phosphorylate the tumor suppressor protein p53, which is the guardian of the genome². The CK1-DELTA and CK1-EPSILON isoforms have striking sequence similarity both the kinase domain and the non-catalytic C-terminal regions. CK1δ and CK1ε are known to be important regulators in the circadian rhythm of eukaryotic cells. Both these kinases are enriched and anchored in the centrosome, which enables them to influence the activity of regulatory centrosomal proteins³. Increased presence of CK1δ has also been detected in neoplasia, cells of hyperplastic B follicles and advanced B-cell lymphomas in p53-deficient mice².

CK1-DELTA kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.