Casein kinase 1 gamma 3
Family: CK1 (Casein Kinase 1)
CK1 kinases isoforms are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation1. CK1γ isoforms play central role in Wnt signal transduction, which makes CK1γ an attractive target for the treatment of Wnt-pathway dependent cancers3. Increased expression of CK1γ3 was shown in renal cell carcinoma.
CK1-GAMMA3 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Schittek B, Sinnberg T. Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis. Molecular cancer. 2014 Oct 11;13(1):231.
2. Knippschild U, Wolff S, Giamas G, Brockschmidt C, Wittau M, Würl PU, Eismann T, Stöter M. The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Oncology Research and Treatment. 2005;28(10):508-14.
3. Huang H, Acquaviva L, Berry V, Bregman H, Chakka N, O’Connor A, DiMauro EF, Dovey J, Epstein O, Grubinska B, Goldstein J. Structure-based design of potent and selective CK1γ inhibitors. ACS medicinal chemistry letters. 2012 Oct 24;3(12):1059-64.