Casein kinase 2 alpha 1
Synonyms: CSNK2A1, Cka1, Cka2
CK2 is ubiquitously expressed protein kinase, which was originally defined as a serine/threonin kinase, but was also shown to phosphorylate tyrosine residues1. It is involved in the control of cell proliferation and survival, and it is associated with oncogenic activity in transgenic mice and ability to promote transformation in cultured mammalian cells. CK2a, the catalytic subunit of CK2, binds across RNA-polymerase-II-transcribed coding genes and active enhancers according to genome-wide binding analysis2.
CK2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Vilk G, Weber JE, Turowec JP, Duncan JS, Wu C, Derksen DR, Zien P, Sarno S, Donella-Deana A, Lajoie G, Pinna LA. Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells. Cellular signalling. 2008 Nov 30;20(11):1942-51.
2. Basnet H, Su XB, Tan Y, Meisenhelder J, Merkurjev D, Ohgi KA, Hunter T, Pillus L, Rosenfeld MG. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. Nature. 2014 Dec 11;516(7530):267-71.
3. Raaf J, Brunstein E, Issinger OG, Niefind K. The CK2α/CK2β interface of human protein kinase CK2 harbors a binding pocket for small molecules. Chemistry & biology. 2008 Feb 22;15(2):111-7.