CDC like kinase 4
Clk(1–4) are CDC2-like kinases with dual specificity, they can autophosphorylate at tyrosine residues and phosphorylate their substrates on serine/threonine residues. CLKs are mainly found in the cytoplasm and in the nucleus where they are implicated in alternative splicing control1. Inhibition of CLKs 1, 2 or 4 accelerates midbody resolution in normally segregating cells and correlates with premature abscission, chromatin breakage and generation of DNA damage in cytokinesis with trapped chromatin.
CLK4 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Petsalaki E, Zachos G. Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint. Nature communications. 2016;7.