Discoidin domain receptor tyrosine kinase 1
Synonyms: CD167, RTK6, CAK, EDDR1, NEP, NTRK4, PTK3A
DDR1 is a receptor tyrosine kinase, which plays a important role in a variety of cancers1. DDRs are unique due to their ability to bind to triple-helical collagens, which are major extracellular matrix components. DDR1 expression is particularly high in highly-proliferative invasive tumors (of the breast, ovary, esophagus, brain and lung)2, which has advised that the DDR1 may be referred to in the proliferation and interstitial infiltration of tumor cells.
DDR1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Song, J., Chen, X., Bai, J., Liu, Q., Li, H., Xie, J., … & Zheng, J. Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumor Biology, 2016, 37(8), 11509-11521.
2. Park, H. S., Kim, K. R., Lee, H. J., Choi, H. N., Kim, D. K., Kim, B. T., & Moon, W. S. (2007). Overexpression of discoidin domain receptor 1 increases the migration and invasion of hepatocellular carcinoma cells in association with matrix metalloproteinase. Oncology reports, 2007, 18(6), 1435-1441.