Discoidin domain receptor tyrosine kinase 2
Synonyms: TKT, NTRKR3, TYRO10
DDR2 is a receptor tyrosine kinase, which plays a important role in a variety of cancers. DDRs are unique due to their ability to bind to triple-helical collagens, which are major extracellular matrix components1. DDR2 is exclusively activated by fibrillar collagen2. It is expressed only in mesenchymal stromal cells, where it regulates extracellular matrix synthesis and participates in wound healing. There is evidence that DDRs play a role in cancer progression by regulating the interactions of tumor cells with their surrounding collagen matrix3.
DDR2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Song, J., Chen, X., Bai, J., Liu, Q., Li, H., Xie, J., … & Zheng, J. Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumor Biology, 2016, 37(8), 11509-11521.
2. Gonzalez, M. E., Martin, E. E., Anwar, T., Arellano-Garcia, C., Medhora, N., Lama, A., … & Ge, C. Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. Cell reports, 2017, 18(5), 1215-1228.
3. Valiathan, R. R., Marco, M., Leitinger, B., Kleer, C. G., & Fridman, R. Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer and Metastasis Reviews, 2012, 31(1-2), 295-321.