DNA-dependent protein kinase
Synonyms: DNA-PKcs, DNAPK, DNPK1, p350, XRCC7, HYRC, HYRC1
DNA-PK is a serine/threonine protein kinase complex, which governs the response to DNA damage, serving to maintain genome integrity1. DNA-PK has dual functions in both DNA repair and gene regulation that promote tumor cell survival and progression, both in the presence and absence of genomic damage.
DNA-PK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Goodwin JF, Knudsen KE. Beyond DNA repair: DNA-PK function in cancer. Cancer discovery. 2014 Oct 1;4(10):1126-39.