Dual specificity tyrosine phosphorylation regulated kinase 1A
Synonyms: DYRK, DYRK1, MNBH
DYRK1A is a dual specificity tyrosine kinase, which is shown to be involved in cell cycle and differentiation regulation, T cell regulation, cytoskeleton stabilization, brain neurodevelopment, and synaptic activities1. DYRK1A hyperactivity is a associated with the development of a number of human malignancies and to cognitive deficits observed in Down syndrome and Alzheimer’s disease.
DYRK1A kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Nguyen TL, Fruit C, Hérault Y, Meijer L, Besson T. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: A survey of recent patent literature. Expert opinion on therapeutic patents. 2017 Nov 2;27(11):1183-99.