Dual specificity tyrosine phosphorylation regulated kinase 1B
Synonyms: “minibrain-related kinase”, MIRK
DYRK1B is a dual specificity tyrosine kinase, which acts as a checkpoint kinase that controls the switch from a non-cycling G0 state to S phase and counteracts oxidative stress1. DYRK1B inhibitors sensitize cells to the cytotoxic effects of anti-cancer drugs that target proliferating cells by disrupting the quiescent state and chemoresistance of non-cycling cancer cells.
DYRK1B kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Becker W. A wake‐up call to quiescent cancer cells–potential use of DYRK1B inhibitors in cancer therapy. The FEBS journal. 2017 Nov 28.