Dual specificity tyrosine phosphorylation regulated kinase 2
DYRK2 is a dual specificity tyrosine kinase, which could phosphorylate both Ser/Thr and Tyr substrates1. DYRK2 regulates p53 through phosphorylation of S46 to induce apoptosis in response to DNA damage2. Down-regulation of DYRK2 is associated with a G2/M arrest1.
DYRK2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Yan H, Hu K, Wu W, Li Y, Tian H, Chu Z, Koeffler HP, Yin D. Low expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) correlates with poor prognosis in colorectal cancer. PloS one. 2016 Aug 17;11(8):e0159954.
2. Taira N, Nihira K, Yamaguchi T, Miki Y, Yoshida K. DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Molecular cell. 2007 Mar 9;25(5):725-38.