Dual specificity tyrosine phosphorylation regulated kinase 3
Synonyms: “dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5”, hYAK3-2, RED, REDK, “regulatory erythroid kinase”
DYRK3 is a dual specificity tyrosine kinase, which could phosphorylate both Ser/Thr and Tyr substrates. DYRK3 is present in hematopoietic tissues, but is expressed at significant levels only in erythroid or erythropoietin (EPO)-responsive cells1. DYRK3 can also stimulate a CREB/CRE response pathway through phosphorylation of the CREB transactivation domain2.
DYRK3 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Lord KA, Creasy CL, King AG, King C, Burns BM, Lee JC, Dillon SB. REDK, a novel human regulatory erythroid kinase. Blood. 2000 May 1;95(9):2838-46.
2. Li K, Zhao S, Karur V, Wojchowski DM. DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival. Journal of Biological Chemistry. 2002 Dec 6;277(49):47052-60.