Epidermal growth factor receptor
Synonyms: “erb-b2 receptor tyrosine kinase 1”, ERBB1, “erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)”, ERBB
Family: TK (tyrosine kinases)
EGFR plays an important role in initiating the signalling that directs the behaviour of epithelial cells and tumours of epithelial cell origin1. EGFR is over-expressed in the majority of solid tumours, and has been associated with malignant progression, inhibition of apoptosis, neoplastic angiogenesis, enhanced metastatic potential, and both chemoresistance and radioresistance2.
EGFR kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Herbst RS. Review of epidermal growth factor receptor biology. International Journal of Radiation Oncology• Biology• Physics. 2004 Jun 1;59(2):S21-6.
2. Herbst RS, Langer CJ. Epidermal growth factor receptors as a target for cancer treatment: the emerging role of IMC-C225 in the treatment of lung and head and neck cancers. InSeminars in oncology 2002 Feb 1 (Vol. 29, No. 1, pp. 27-36). Elsevier.