Eukaryotic translation initiation factor 2 alpha kinase 1
Synonyms: HRI, “heme regulated initiation factor 2 alpha kinase”, KIAA1369
EIF2AK1 is eIF-2α kinase, which is activated under conditions of heme deficiency in immature erythroid cells, and its activity is inhibited by heme1. Its major physiological role is the regulation of protein synthesis, particularly of hemoglobin, according to the concentration of heme in these cells.
EIF2AK1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Chen JJ, London IM. Regulation of protein synthesis by heme-regulated eIF-2α kinase. Trends in biochemical sciences. 1995 Mar 1;20(3):105-8.