Eukaryotic translation initiation factor 2 alpha kinase 2
Synonyms: EIF2AK1, PKR, PPP1R83, “protein phosphatase 1, regulatory subunit 83”, PRKR
EIF2AK2 is the double-stranded-RNA-dependent eIF-2α kinase1. It is activated during a viral infection by the binding of double-stranded RNA to its two conserved binding domains2.
EIF2AK2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Chen JJ, London IM. Regulation of protein synthesis by heme-regulated eIF-2α kinase. Trends in biochemical sciences. 1995 Mar 1;20(3):105-8.
2. Taniuchi S, Miyake M, Tsugawa K, Oyadomari M, Oyadomari S. Integrated stress response of vertebrates is regulated by four eIF2α kinases. Scientific reports. 2016 Sep 16;6:32886.