EPH-A1 assay
EPH receptor A1
Synonyms: EPH, EPHT, EPHT1
Family: TK
EPHA1 is a receptor tyrosine kinase that plays a key role in developmental processes, including guidance of the migration of axons and cells in the nervous system1. Binding and activation of Eph-receptor family members requires cell-cell interactions2.
EPHA1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Chavent M, Chetwynd AP, Stansfeld PJ, Sansom MS. Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: insights into the mechanism of receptor activation. Biochemistry. 2014 Oct 17;53(42):6641-52.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.