EPH receptor A2
EPHA2 is a receptor tyrosine kinase that is expressed during embryonic development and in adult epithelia where it regulates cell adhesion1. EPHA2 was shown to participate in a number of cancers by promoting vascularisation and metastasis. Binding and activation of Eph-receptor family members requires cell-cell interactions2.
EPHA2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Seiradake E, Harlos K, Sutton G, Aricescu AR, Jones EY. An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly. Nature Structural and Molecular Biology. 2010 Apr;17(4):398.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.