EPH-A3 assay
EPH receptor A3
Synonyms: HEK, HEK4, ETK, ETK1, TYRO4
Family: TK
EPHA3 is a receptor tyrosine kinase that is involved in cell viability, cell movement and cell-cell interactions1. Binding and activation of Eph-receptor family members requires cell-cell interactions2. High levels of EphA3 protein expression have been reported in colorectal, prostate, and gastric cancers, whereas loss of protein expression has been reported in lung and hematopoietic cancers3.
EPHA3 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Nasri B, Inokuchi M, Ishikawa T, Uetake H, Takagi Y, Otsuki S, Kojima K, Kawano T. High expression of EphA3 (erythropoietin-producing hepatocellular A3) in gastric cancer is associated with metastasis and poor survival. BMC clinical pathology. 2017 Dec;17(1):8.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.
3. Wang X, Xu H, Cao G, Wu Z, Wang J. Loss of EphA3 Protein Expression Is Associated With Advanced TNM Stage in Clear-Cell Renal Cell Carcinoma. Clinical genitourinary cancer. 2017 Apr 1;15(2):e169-73.