EPH-A5 assay
EPH receptor A5
Synonyms: CEK7, EHK1, Hek7, TYRO4
Family: TK
EPHA5 is a receptor tyrosine kinase that is mostly recognized for its critical role in axonal guidance during embryonic development1. Binding and activation of Eph-receptor family members requires cell-cell interactions2. EphA5 is specifically overexpressed in lung cancer and is involved in regulating cellular responses to genotoxic insult.
EPHA5 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Staquicini FI, Qian MD, Salameh A, Dobroff AS, Edwards JK, Cimino DF, Moeller BJ, Kelly P, Nunez MI, Tang X, Liu DD. Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer. Journal of Biological Chemistry. 2015 Mar 20;290(12):7345-59.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.