EPH receptor A6
EPHA6 is a receptor tyrosine kinase that plays key roles in brain development1. Binding and activation of Eph-receptor family members requires cell-cell interactions2. Correlation between EPHA6 and prostate cancer progression means that EPHA6 may be a therapeutic target in metastatic prostate cancer3.
EPHA6 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Das G, Yu Q, Hui R, Reuhl K, Gale NW, Zhou R. EphA5 and EphA6: regulation of neuronal and spine morphology. Cell & bioscience. 2016 Dec;6(1):48.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.
3. Li S, Ma Y, Xie C, Wu Z, Kang Z, Fang Z, Su B, Guan M. EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression. Oncotarget. 2015 Sep 8;6(26):22587.