EPH-A7 assay
EPH receptor A7
Synonyms: Hek11
Family: TK
EPHA7 is a receptor tyrosine kinase that is shown to act as tumor suppressor in the relevant tumors1. Binding and activation of Eph-receptor family members requires cell-cell interactions2. EPHA7 is often down regulated in epithelial cancers and linked to tumor progression.
EPHA7 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Li S, Wu Z, Ma P, Xu Y, Chen Y, Wang H, He P, Kang Z, Yin L, Zhao Y, Zhang X. Ligand-dependent EphA7 signaling inhibits prostate tumor growth and progression. Cell death & disease. 2017 Oct;8(10):e3122.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.