EPH receptor B3
Synonyms: Hek2, Tyro6, ETK2
EPHB3 is a receptor tyrosine kinase that is expressed during embryonic development and in discrete areas of the adult brain, including the cerebellum and hippocampus1. Binding and activation of Eph-receptor family members requires cell-cell interactions2. EPHB3 is up regulated in prostate cancer and melanoma3.
EPHB3 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Qiao L, Choi S, Case A, Gainer TG, Seyb K, Glicksman MA, Lo DC, Stein RL, Cuny GD. Structure–activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorganic & medicinal chemistry letters. 2009 Nov 1;19(21):6122-6.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.
3. Xi HQ, Wu XS, Wei B, Chen L. Eph receptors and ephrins as targets for cancer therapy. Journal of cellular and molecular medicine. 2012 Dec 1;16(12):2894-909.