EPH receptor B4
Synonyms: Tyro11, HTK
EPHB4 is a receptor tyrosine kinase that is together with its cognitive ligand ephrin B2 play an important role in embryonic vessel development and vascular remodeling1. Binding and activation of Eph-receptor family members requires cell-cell interactions2. EPHB4 is up regulated in breast and colorectal cancers and brain tumours3.
EPHB4 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Martiny-Baron G, Holzer P, Billy E, Schnell C, Brueggen J, Ferretti M, Schmiedeberg N, Wood JM, Furet P, Imbach P. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep 1;13(3):259-67.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.
3. Xi HQ, Wu XS, Wei B, Chen L. Eph receptors and ephrins as targets for cancer therapy. Journal of cellular and molecular medicine. 2012 Dec 1;16(12):2894-909.