ERBB4/HER4 assay
Erb-b2 receptor tyrosine kinase 4
Synonyms: ALS19, HER4, “human epidermal growth factor receptor 4”
Family: TK
ERBB4 is a receptor tyrosine kinase that is part of the epidermal growth factor (EGF) family1. ERBB4 is essential to cardiac, mammary, and neural development and is implicated in schizophrenia2. ERBB4 overexpression was associated with melanoma, medulloblastoma, and breast cancer progression.
ERBB4 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Mitri Z, Constantine T, O’Regan R. The HER2 receptor in breast cancer: pathophysiology, clinical use, and new advances in therapy. Chemotherapy research and practice. 2012 Dec 20;2012.
2. Jones DC, Scanteianu A, DiStefano M, Bouhaddou M, Birtwistle MR. Analysis of copy number loss of the ErbB4 receptor tyrosine kinase in glioblastoma. PloS one. 2018 Jan 17;13(1):e0190664.