ERK5 assay
Mitogen-activated protein kinase 7
Synonyms: MAPK7, BMK1, “BMK1 kinase”, ERK5, “extracellular-signal-regulated kinase 5”, PRKM7
Family: CMGC
ERK5 is a member of the mitogen-activated protein kinase family that is activated by growth factors and have an important role in the regulation of cell proliferation and cell differentiation1. ERK5 together with its upstream activator MAPK kinase 5 mediate MAPK pathway2. Importantly abnormal ERK5 expression has been reported in several types of human cancer, including colon cancer.
ERK5 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Nishimoto S, Nishida E. Mapk signalling: Erk5 versus erk1/2. EMBO reports. 2006 Aug 1;7(8):782-6.
2. Pereira DM, Simões AE, Gomes SE, Castro RE, Carvalho T, Rodrigues CM, Borralho PM. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016 Jun 7;7(23):34322.