Protein tyrosine kinase 2
Synonyms: FADK, FAK, FAK1, PPP1R71, “protein phosphatase 1, regulatory subunit 71”, “focal adhesion kinase”
FAK is a cytoplasmic tyrosine kinase that plays critical roles in integrin-mediated signal transductions and also participates in signaling by other cell surface receptors1. The activated FAK forms a complex with Src family kinases and initiates multiple downstream signaling pathways important for cell migration and angiogenesis. FAK was shown to play a critical role of FAK in angiogenesis during embryonic development and cancer progression2,3.
FAK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Zhao X, Guan JL. Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Advanced drug delivery reviews. 2011 Jul 18;63(8):610-5.
2. Guan JL, Shalloway D. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature. 1992 Aug;358(6388):690.
3. McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, Frame MC. The role of focal-adhesion kinase in cancer—a new therapeutic opportunity. Nature Reviews Cancer. 2005 Jul;5(7):505.