FER tyrosine kinase
Synonyms: “phosphoprotein NCP94”, PPP1R74, “protein phosphatase 1, regulatory subunit 74”, TYK3, “feline sarcoma and feline sarcoma-related kinase”
FER is a non-receptor tyrosine kinase, which is ubiquitously expressed and localised in cytoplasm throughout the cell cycle1. FER regulates cell cycle progression in prostate and breast cancer, as well as in acute myeloid leukaemia cells2.
FER kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Zirngibl R, Schulze D, Mirski SE, Cole SP, Greer PA. Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking. Experimental cell research. 2001 May 15;266(1):87-94.
2. Ivanova IA, Vermeulen JF, Ercan C, Houthuijzen JM, Saig FA, Vlug EJ, Van Der Wall E, Van Diest PJ, Vooijs MA, Derksen PW. FER kinase promotes breast cancer metastasis by regulating α 6-and β 1-integrin-dependent cell adhesion and anoikis resistance. Oncogene. 2013 Dec;32(50):5582.