Fibroblast growth factor receptor 1
Synonyms: BFGFR, CD331, CEK, FLG, H2, H3, H4, H5, N-SAM, FLT2, KAL2 “Pfeiffer syndrome”
The fibroblast growth factor is a receptor tyrosine kinase signaling pathway that fundamentally regulates embryogenesis, angiogenesis, tissue homeostasis, and wound repair1. Alterations in FGFR signaling are associated with a broad range of congenital craniofacial developmental disorders, and somatic mutations of FGFR also have a role in oncologic evolution. FGFR1 is one of the 4 highly conserved transmembrane tyrosine kinase receptors. Activated FGFR1 recruits the fibroblast growth factor receptor substrate 2 adaptor protein, and the FGFR1–FRS2 complex is in the forefront of downstream survival signaling, including that involving PI3K-AKT and mitogen-activated protein kinase cascades2.
FGFR1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Chae YK, Ranganath K, Hammerman PS, Vaklavas C, Mohindra N, Kalyan A, Matsangou M, Costa R, Carneiro B, Villaflor VM, Cristofanilli M. Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application. Oncotarget. 2017 Feb 28;8(9):16052.
2. Adachi Y, Watanabe K, Kita K, Kitai H, Kotani H, Sato Y, Inase N, Yano S, Ebi H. Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer. Carcinogenesis. 2017 Aug 31;38(11):1063-72.