Fms related tyrosine kinase 1
Synonyms: “vascular endothelial growth factor receptor 1”, “vascular permeability factor receptor”, VEGFR1, FLT
FLT1 is a tyrosine kinase and vascular endothelial growth factor receptor, which is classically described as a decoy receptor that does not produce intracellular signals. Recent evidence suggest though that FLT1 promotes cell migration and proliferation through PLCγ and PI3K pathways1. FLT1 (or VEGFR1) acts a predictive biomarker for anti-VEGF efficacy.
FLT1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Weddell JC, Chen S, Imoukhuede PI. VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways. NPJ Systems Biology and Applications. 2017 Dec 19;4(1):1.