Fms related tyrosine kinase 4
Synonyms: PCL, VEGFR3
FLT4 is a receptor tyrosine kinase of vascular endothelial growth factors C and D. The protein is mainly expressed in lymphatic endothelial cells and thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. It is also expressed in neovascular endothelial cells of the liver, splenic sinusoid, trauma repair tissues and tumor tissue1.
FLT4 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Zhang S, Yu H, Zhang L. Role of vascular endothelial growth factor receptor-3/Flt-4 in early-stage cervical cancer. Oncology letters. 2010 May 1;1(3):453-6.