FMS assay
Colony stimulating factor 1 receptor
Synonyms: C-FMS, CD115, CSFR
Family: TK
FMS is a type III receptor tyrosine kinase that binds to the macrophage or monocyte colony-stimulating factor controlling survival, proliferation, and differentiation of monocyte/macrophage lineage. It was first discovered as the oncogene responsible for Feline McDonough Sarcoma, and overexpression of FMS has been implicated in a number of disease states such as the growth of metastasis of certain types of cancer, in promoting osteoclast proliferation in bone osteolysis, and many inflammatory disorders1.
FMS kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. El‐Gamal MI, Anbar HS, Yoo KH, Oh CH. FMS kinase inhibitors: current status and future prospects. Medicinal research reviews. 2013 May 1;33(3):599-636.