Mechanistic target of rapamycin kinase
Synonyms: MTOR, “FKBP12-rapamycin complex-associated protein 1”, FLJ44809, “mammalian target of rapamycin”, RAFT1, “rapamycin and FKBP12 target 1”, “rapamycin associated protein FRAP2”, RAPT1, FRAP, FRAP1, FRAP2
FRAP1 (or MTOR) belongs to the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family. It is central protein in mTOR protein pathway, which controls cell growth in response to energy, nutrients, growth factors and other environmental cues, and figures prominently in cancer1.
FRAP1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Yang H, Rudge DG, Koos JD, Vaidialingam B, Yang HJ, Pavletich NP. mTOR kinase structure, mechanism and regulation. Nature. 2013 May;497(7448):217.