Glycogen synthase kinase 3 alpha
GSK3 is a protein kinase, which phosphorylates and inactivates the metabolic enzyme glycogen synthase. GSK3 was found to be a broadly influential enzyme in neural systems that modulates many aspects of neuronal function, such as gene expression, neurogenesis, synaptic plasticity, neuronal structure, and neuronal death and survival1. GSK3-ALPHA and GSK3-BETA are paralogous proteins, which are often referred as isoforms of GSK3. GSK3 isoforms are partially active in unstimulated cells, and they are regulated predominantly in an inhibitory manner by similar signaling mechanisms. Both isoforms were shown to play role in Alzheimer’s disease pathogenesis2.
GSK3-ALPHA kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Li X, Jope RS. Is glycogen synthase kinase-3 a central modulator in mood regulation?. Neuropsychopharmacology. 2010 Oct;35(11):2143.
2. Ma T. GSK3 in Alzheimer’s disease: mind the isoforms. Journal of Alzheimer’s Disease. 2014 Jan 1;39(4):707-10.