Hematopoietic cell kinase
Synonyms: JTK9, “hemopoietic cell kinase”
HCK is a cytoplasmic tyrosine kinase and a member of Src family1. It is expressed in lymphoid and myeloid cells and is bound to B-cell receptors in unstimulated B-cells2. Once activated, HCK engages a range of downstream signaling pathways that mediate various aspects of the immune response
HCK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Poh AR, O’Donoghue RJ, Ernst M. Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells. Oncotarget. 2015 Jun 30;6(18):15752.
2. Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. Nature. 1997 Feb;385(6617):602.