Hepatocyte progenitor kinase-like/germinal center kinase-like kinase
Synonyms: MAP4K4, FLH21957, “HPK/GCK-like kinase”, NIK
HGK is a member of the human STE20/mitogen-activated protein kinase kinase kinase kinase family of serine/threonine kinases1. HGK is expressed in all tissue types, but appears to express at relatively higher levels in the brain and testis. HGK plays essential role in embryonic development, and has also been implicated in focal adhesion dynamics regulation, systemic inflammation, lung inflammation, type 2 diabetes, atherosclerosis, and insulin sensitivity2.
HGK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Wright JH, Wang X, Manning G, LaMere BJ, Le P, Zhu S, Khatry D, Flanagan PM, Buckley SD, Whyte DB, Howlett AR. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. Molecular and cellular biology. 2003 Mar 15;23(6):2068-82.
2. Gao X, Gao C, Liu G, Hu J. MAP4K4: an emerging therapeutic target in cancer. Cell & bioscience. 2016 Dec;6(1):56.