INSR is tyrosine kinase and transmembrane receptor, which is activated by insulin, IGF-I and IGF-II. INSR initiates a cascade of cellular phosphorylation reactions that regulate protein interactions and enzymatic activities. Substrates of the INSR include the insulin receptor substrates IRS-1 and IRS-2, as well as Shc and APS1.
INSR kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Youngren JF. Regulation of insulin receptor function. Cellular and Molecular Life Sciences. 2007 Apr 1;64(7-8):873.