Interleukin 1 receptor associated kinase 1
Synonyms: IRAK, pelle
IRAK1 is serine/threonine kinase that regulates various signaling events from Toll-like receptors to transcription factors in inflammatory cells such as macrophages1. Activation of IRAK1 requires its phosphorylation on threonine 209, followed by recruitment of TRAF6, leading to the activation of transforming growth factor β-activated kinase 1 and mitogen-activated protein kinase.
IRAK1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Hossen MJ, Yang WS, Kim D, Aravinthan A, Kim JH, Cho JY. Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. Scientific reports. 2017 Feb 20;7:42995.