IL2 inducible T-cell kinase
Synonyms: EMT, LYK, PSCTK2
ITK is one of the five Tec tyrosine kinases, which are involved in multiple receptor-mediated signaling pathways in many cell types. ITK is essential mediator of intracellular signaling in T-cells and was shown to be activated via T-cell receptor (TCR) stimulation1. ITK inhibitors have therapeutic potential in a number of human autoimmune, inflammatory, and malignant diseases2.
ITK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Andreotti AH, Schwartzberg PL, Joseph RE, Berg LJ. T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harbor perspectives in biology. 2010 Jul 1;2(7):a002287.
2. Zhong Y, Dong S, Strattan E, Ren L, Butchar JP, Thornton K, Mishra A, Porcu P, Bradshaw JM, Bisconte A, Owens TD. Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694. Journal of Biological Chemistry. 2015 Mar 6;290(10):5960-78.