Janus kinase 2
JAK2 is a human tyrosine kinase protein, which has been implicated in signal transduction processes initiated by a variety of growth factors and cytokines1. JAK1 and JAK2 ply role in signaling by IL-3, GM-CSF and IL-5. JAK2 can be also activated following erythropoietin stimulation of its receptor and upon IL-12 stimulation and is proposed to play a critical role in IL-12 mediated T-cell differentiation.
JAK2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Rane SG, Reddy EP. Janus kinases: components of multiple signaling pathways. Oncogene. 2000 Nov;19(49):5662.