JUN N-terminal kinase 3
Synonyms: p493F12, p54bSAPK, PRKM10, MAPK10
JNK3 is a member of c-Jun N-terminal kinases family that plays a central role in stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration, cell death, and regulation of cellular senescence1. JNK pathway was shown to be activated following exposure to different stressing factors, including cytokines, growth factors, oxidative stress, unfolded protein response signals or Aβ peptides. JNK3 is mainly localized in neurons and plays important role in controlling brain functions under both normal and pathological conditions
JNK3 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Yarza R, Vela S, Solas M, Ramirez MJ. c-Jun N-terminal kinase (JNK) signaling as a therapeutic target for Alzheimer’s disease. Frontiers in pharmacology. 2016 Jan 12;6:321.