LATS2 assay
Large tumor suppressor kinase 2
Synonyms: –
Family: AGC
LATS2 is one out of two Large tumour suppressor kinases (LATS1/2). LATS1/2 deletion leads to tumour regression through adaptive immune responses, and enhances tumour vaccine efficacy. LATS1/2 are part of the Hippo pathway, and LATS1/2-null tumor cells secrete nucleic-acid-rich extracellular vesicles, which induce a type I interferon response via the Toll-like receptors-MYD88/TRIF pathway1.
LATS2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL. The Hippo pathway kinases LATS1/2 suppress cancer immunity. Cell. 2016 Dec 1;167(6):1525-39.